Depression is a difficult illness especially when doctors are telling you the thyroid has no part in it (which is odd since my symptoms started just before my thyroid was removed due to thyroid cancer). I started thyroid medication, T4, 21 months ago and I have changed doses every 3 months because I have gone from hyper, to not hyper enough, to too hyper, and so on. When I asked my endocrinologist about the weight gain he said it didn't have anything to do with losing my thyroid so in his opinion it was my depression medicine. He didn't test anything else, he just sent me on my way. I had already tried several depression medicines with my family doctor for 1 year. When he felt he couldn't help me any longer, he sent me to a psychiatrist. My psychiatrist is compassionate and tends to be better at looking at the whole picture so after my endocrinologist said the weight was from my medication, the psychiatrist and I changed my medicine to something that was shown to cause less weight gain. As of late these ongoing medicine trials have not brought much relief in terms of the depression or the weight gain. Recently he suggested I consider using Ketamine an IV drug which is costly, but has shown some positive results in helping depressed patients. After doing my own research on the thyroid and depression I had come across the concept of combining T4 and T3 medications to decrease some of the hypothyroidism symptoms. There is a lot of great information out there about how this works, but I won't go in to detail here. At this point I had two choices: 1) go with the Ketamine which is somewhat experimental or 2) rule out any other causes of depression and find an endocrinologist who would consider T3 medication. I decided to rule out as many causes as I could. I went to my doctor and we did several blood tests including B12 and calcium which are just some of the deficiencies that can cause depression. Next was switching endocrinologist to someone I felt would be more open to listening to me. The doctor I found specialized in thyroid cancer which was a major plus. My first appointment was anxiety-filled because I was terrified she wouldn't listen. I was afraid she wouldn't even consider T3. What would I do then! I was running out of things to try. I cried the entire appointment and could barely think, but to my amazement she agreed to add T3. It's been about a month since that appointment and although I haven't seen a ton of improvement I have renewed hope which keeps me going day to day. It will take another month or two to see the full effect of my latest medicine regimen, but with hope that this medication rollercoaster may be over soon I do my best to move forward.